A Case of Hiccough Cured with Apomorphine Hydrochloride

Apomorphine Hydrochloride in the Treatment of Persistent Hiccough

most powerful emetic in the British Pharmacopoeia, and as such it is extensively used in cases of poisoning. As an expectorant also it is prescribed in cases of chronic bronchitis; I have never however seen it used for other conditions. Professors Savill and Osier advocate the use of the drug (in doses of 1110th to 118 of a grain) in cases of hiccough, but they do not explain how the drug acts ...

Sonographic Characterisation of Tissue Changes Associated with Infused Apomorphine Hydrochloride: A Case Series

Apomorphine hydrochloride is used to treat refractory motor fluctuations in advanced Parkinson’s disease. Delivery by infusion is associated with the formation of hard subcutaneous nodules, which may be painful, limit available infusion sites, and interfere with absorption of the drug. Diagnostic ultrasound was used to image affected tissue in 12 people experiencing apomorphine nodule formation...

Effect of low concentrations of apomorphine on parkinsonism in a randomized, placebo-controlled, crossover study.

OBJECTIVE To determine whether low concentrations of a dopamine agonist worsen parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors causes a super-off state. DESIGN Randomized, double-blind, placebo-controlled, crossover clinical trial. SETTING Academic movement disorders center. PATIENTS Patients with Parkinson disease and motor fluctuations. INTERVEN...

Allergic contact dermatitis caused by apomorphine hydrochloride in a carer.

Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.

Apomorphine is a non-selective dopamine D1/D2 receptor agonist, which has been used for patients with Parkinson's disease and reported to induce QT interval prolongation and cardiac arrest. To clarify their causal link, we assessed the cardiovascular and pharmacokinetic profile of apomorphine with the halothane-anaesthetized canine model (n = 4), whereas pro-arrhythmic potential of apomorphine ...